高等学校化学学报2012，Vol.33Issue(11)：2378-2384,7.DOI:10.7503/cjcu20120342
羧基化氧化石墨烯的可控合成及血液相容性
Controlled Synthesis and Blood Compatibility Properties of Carboxyl Graphene Oxide
摘要
Abstract
Carboxyl modifiedgraphene oxide is important in the preparation of functionalized graphene oxide ( GeneO). In this work, the free radical initiator agent azobisisobutyronitrile ( AIBN) was functioned as a modifier. AIBN could be separated into isobutyronitrile radicals to attack the five-membered ring and seven-membered ring defects in the graphene oxide. Then the cyanogroup-modified graphene oxide intermediates were formed, and the carboxyl graphene oxide [GeneO—C(CH3)2—COOH] could be obtained through the hydrolysis reaction. The structure and properties of GeneO—C(CH3)2—COOH were characterized by Fourier transform infrared spectroscope ( FTIR) , X-ray diffraction ( XRD ) , thermo gravimetric analyzer ( TGA ) and atomic force microscope( AFM). And the blood compatibility of GeneO—C(CH3)2—COOH was evaluated by recalcification time test. It was showed that the recalcification time gradually decreased as the increasing concentration of GeneO—C(CH3)2—COOH, indicating that the material had good blood compatibility. Carboxyl group content could be controlled by the mass ratio of AIBN to GeneO. This method not only could increase the carboxyl content of oxidized graphene, but also made the material have a good blood compatibility.关键词
羧基化氧化石墨烯/偶氮二异丁腈/血液相容性Key words
Carboxyl graphene oxide/ Azobisisobutyronitrile/ Blood compatibility分类
化学化工引用本文复制引用
汤毅达,周宁琳,陆春燕,金素星,吴悦,沈健..羧基化氧化石墨烯的可控合成及血液相容性[J].高等学校化学学报,2012,33(11):2378-2384,7.基金项目
江苏省自然科学基金(批准号:BK2009408)、国家自然科学基金(批准号:20874047)、江苏高校优势学科建设工程资助项目和江苏省产学研前瞻性联合研究项目(批准号:BY2011109)资助. （批准号:BK2009408）
