国际医药卫生导报2012，Vol.18Issue(21)：3164-3166,3.DOI:10.3760/cma.j.issn.1007-1245.2012.21.030
降钙素原在颅内感染患者中的临床意义
The clinical significance of procalcitonin in patients with intracranial infection
方浩威 1黄晓芸 1梅志忠 1余映丽 1林菡1
作者信息
摘要
Abstract
Objective To investigate the values and clinical significance of procalcitonin(PCT)determination in the diagnosis of intracranial infection.Methods 62 patients with acute meningitis were divided into bacterial meningitis group and viral meningitis group according to the type of infection.Serum PCT levels were detected at different stages of meningitis and cerebrospinal fluid was analyzed.Results PCT levels were(26.43±15.32)μg/L in the acute phase of bacterial meningitis and significantly higher than the normal level;after treatment,they were(5.85±5.43)/ag/L on day 3,(0.21±0.26)μg/L on day 5,and(0.06±0.12)μg/L on day 7,being significantly reduced(P<0.05).PCT levels were(1.64±3.25)μg/L in the acute phase and(0.83±3.12)μg/L on day 3 in viral encephalitis group,which were significantly lower than those in bacterial meningitis group(P<0.05).CRP levels did not differ significantly between the two groups[(28.3±15.3)(5-110)mg/L vs.(27.3±16.4)(0-45)mg/L,P＞0.05].There were significant differences between the two groups in leukocyte count and protein level in CSF[(287±15)(24-590)×lO6 vs.(17±5)(6-120)×l06 and(1.68±0.36)(0.4-4.8)mg/L vs.(0.67±0.32)(O.1-2.5)mg/L,P<0.05],but there was a overlap in the two groups.Conclusions Serum procalcitonin determination has important clinical significance in the early differential diagnosis of bacterial meningitis with viral encephalitis.关键词
降钙素原/颅内感染/临床意义Key words
Procalcitonin/Intracranial infection/Clinical significance引用本文复制引用
方浩威,黄晓芸,梅志忠,余映丽,林菡..降钙素原在颅内感染患者中的临床意义[J].国际医药卫生导报,2012,18(21):3164-3166,3.
