国际医药卫生导报2012，Vol.18Issue(22)：3239-3241,3.DOI:10.3760/cma.j.issn.1007-1245.2012.22.002
血清中性粒细胞弹性蛋白酶和α1-抗胰蛋白酶检测COPD的意义研究
Significance of serum neutrophil cell elastase and α 1-antitrypsin detection of COPD
摘要
Abstract
Objective To select patients with chronic obstructive pulmonary disease(COPD)and healthy people for comparative study and analysis during the stabilization period of the patients with COPD exacerbation of neutrophil elastase and α 1-antitrypsin(α 1-AT)change status,and the changes,risk factors and lung function indicators of relevance,and to explore the significance of anti-proteases and protease imbalance in the pathogenesis of COPD.Methods We randomly collected 43 cases of COPD from February 2009 to January 2012 as acute exacerbation group,and 24 cases of healthy people as controls,taking their serum samples,patients with COPD including 21 cases of acute exacerbation with the stabilization period among 22 cases to detect serum α 1-AT,NE level,using the enzyme-linked immunosorbent assay.Results NE level in normal control group was significantly lower than that of the acute exacerbation group,the difference was statistically significant(P＜ 0.01).the NE level of stabilization period was less than that of acute exacerbation with statistical significant difference(P＜ 0.05);Independent samples T-test results,acute exacerbation phase group α 1-AT level was significantly lower than that of the control group,the difference was statistically significant(P＜ 0.01);acute exacerbation α 1-AT levels below the stabilization period,the difference was statistically significant(P＜ 0.05).Conclusion The imbalance of α 1-AT and the NE level plays an important role in the pathogenesis of COPD;the α 1-AT deficiency and increase of NE level are closely associated with airway obstruction and airway inflammation.关键词
血清中性粒细胞弹性蛋白酶/α1-抗胰蛋白酶检测/COPDKey words
Serum neutrophil cell elastase/α 1-antitrypsin detection(α 1-AT)/Chronic obstructive pulmonary disease(COPD)引用本文复制引用
刘华,陈艳波,王洪云,钟亮尹,李兰英..血清中性粒细胞弹性蛋白酶和α1-抗胰蛋白酶检测COPD的意义研究[J].国际医药卫生导报,2012,18(22):3239-3241,3.基金项目
广东省自然科学基金项目(S2011010002100) （S2011010002100）
