湖南中医药大学学报2012，Vol.32Issue(11)：54-57,4.DOI:10.3969/j.issn.1674-070X.2012.11.016.054.04
参竹心康汤对慢性心衰患者的临床疗效及血管内皮功能的影响
Clinical study of the effects of Shenzhu Xinkang decoction on the function of vascular endothelium of patients with chronic heart failure
摘要
Abstract
Objective To observe the effects of Shenzhu Xinkang decoction on the heart function and vascular endothelium function of patients with chronic heart failure. Methods 91 patients with chronic heart failure were enrolled and randomly divided into the treatment group (n=46) and the control group (n=45). All patients were managed with conventional western medicine therapy.In addition, the patients in treatment group were administered by Shenzhu Xinkang decoction. The indices of the patients were observed as follow: endothelin (ET), calcitonin gene related peptide (CGRP), minute volume (CO), left ventricular fractional shortening(FS), left ventricular ejection fraction (LVEF), peak early diastolic velocity (EPFV)/late diastolic peak flow rate(APFV) or (E/A). Results The curative effects of heart failure between the two groups were statistically significant (P< 0.05) and the improvement in TCM syndrome between them were also significantly different (P< 0.01). The expressions of ET and CGRP which were provided objective indices for vascular endothelium function before and after treatment in both groups were statistical significance (P<0.05 or P<0.01), the indices of treatment group were superior to those of control group (P<0.01). The CO, FS and LVEF which were provided objective indices for left ventricle systolic function before and after treatment in both groups were statistical significance (P<0.05 or P<0.01), the indices of treatment group were superior to those of control group (P<0.05 or P<0.01). The E/A which were provided objective index for right ventricle diastolic function between before and after treatment in both groups were statistical significance (P<0.01), the index of treatment group was superior to that of control group (P<0.01). Conclusion Shenzhu Xinkang decoction may be useful for the clinical treatment of chronic heart failure and can improve the function of vascular endothelia and systolic and diastolic function.关键词
参竹心康汤/慢性心衰/血管内皮功能/收缩与舒张功能/临床观察Key words
Shenzhu Xinkang decoction/ chronic heart failure/ vascular endothelium function/ systolic and diastolic function/ clinical study分类
医药卫生引用本文复制引用
喻正科,朱筱婧,陈志红,朱棱,谭宇军..参竹心康汤对慢性心衰患者的临床疗效及血管内皮功能的影响[J].湖南中医药大学学报,2012,32(11):54-57,4.基金项目
湖南省卫生厅中医药科研基金资助项目(2009041). （2009041）
