四川大学学报（医学版）2012，Vol.43Issue(6)：827-829,859,4.
Bcl-2、PD-L1在大肠癌组织中的表达及意义
Expression of Bcl-2, PD-L1 and Its Clinical Significance in Colorectal Cancer
张美云 1杨永岩 1王新花 1李晓凤1
作者信息
- 1. 包头市肿瘤医院 综合内科,包头 014030
- 折叠
摘要
Abstract
Objective To study the expression of Bcl-2 and PD-L1 in colon cancer and its relationship with metastasis. Methods Tumor samples were collected from 57 cases of colon cancer, and tumor adjacent normal mucous tissue were obtained as normal control. The expressions of Bcl-2 and PD-L1 were assayed by immunohistochemical staining, and its correlations with patients' clinical pathological indexes were analyzed. Results The positive rate of Bcl-2 protein was 75. 43% and 52. 63% in colon cancer tissues and tumor adjacent colon mucous tissue respectively, with statistically significant difference (P <C 0. 05). While the positive rate of PD-L1 was 45.61% and 15. 79% in colon cancer tissues and tumor adjacent colon mucous tissue respectively, also with signficant difference (P<0. 01). The positive rate of Bcl-2 was correlated with cellular differentiation, and the positive rate of PD-L1 protein was correlated with lymph node metastasis (P<C0. 05). Conclusion The expression of Bcl-2 may be associated with colon cancer pathologic differentiation, and the expression of PD-L1 may be associated with colon cancer metastasis.关键词
Bcl-2/PD-L1/大肠癌/临床病理/淋巴结转移Key words
Bcl-2/PD-L1/Colon cancer/Clinical pathological indexes/Lymph node/metastasis引用本文复制引用
张美云,杨永岩,王新花,李晓凤..Bcl-2、PD-L1在大肠癌组织中的表达及意义[J].四川大学学报（医学版）,2012,43(6):827-829,859,4.
