四川大学学报（医学版）2012，Vol.43Issue(6)：851-854,4.
二氢青蒿素对大鼠牛Ⅱ型胶原蛋白诱导关节炎模型作用的初步研究
Effects of Dihydroartemisinin on Collagen Ⅱ-induced Arthritis in Rats Model
王岩艳 1刘怡欣 2谢其冰 2刘钢2
作者信息
- 1. 青岛市妇女儿童医疗保健中心
- 2. 四川大学华西医院 风湿免疫科,成都 610041
- 折叠
摘要
Abstract
Objective To study the effects of dihydroartemisinin on collagen-induced arthritis (CIA) in rats model. Methods CIA was induced in Male Wistar rats by intradermal injection of emulsion of 0. 3 mg type Ⅱ collagen in Freund's completead juvant (CⅡ /FA) at the base of the tail and repeated one times after 15 days. The normal control rats received the injection of the same volume of saline 52 days later, the CIA rats were divided into dihydroartemisinin treated group, saline treated group, in which the rats were subjected to the treatment of dihydroartemisinin 30 mg/(kg · d) or the same volume of saline for 28 days, then the effects of the treatments on arthritis were evaluated. . Results Compared with the normal rats, the joints of non-treated CIA rats were obviously swollen. After the treatment of dihydroartemisinin. The joints of CIA rats appeared less inflammation cell erosion, less proliferation of fibrous connective tissue and blood capillary, more clear, articular cavity and no bone erosion. Conclusion This preliminary study indicated dihydroartemisinin may have the effects to relieve CIA in rats.关键词
胶原性关节炎/Ⅱ型胶原/类风湿关节炎/二氢青蒿素Key words
Collagen-induced/arthritis/Type Ⅱ/collagen/Rheumatoid/arthritis/Dihydroartemisinin引用本文复制引用
王岩艳,刘怡欣,谢其冰,刘钢..二氢青蒿素对大鼠牛Ⅱ型胶原蛋白诱导关节炎模型作用的初步研究[J].四川大学学报（医学版）,2012,43(6):851-854,4.
