基础医学与临床Issue(9)：1099-1102,4.
瘦素抵抗的免疫调节作用及其与肿瘤发生的关系
The immunomodulation of leptin resistance and its relationship with the development of tumor
摘要
Abstract
Leptin is a multifunctional hormone that regulates energy balance, appetite, reproduction, hematogene-sis et al. Its action is mediated by leptin receptor. Leptin resistance is related with the tumorigenesis and tumor development. Leptin resistance not only plays an important role in the proliferation and apoptosis of cancer cells, but also regulates the quantity and function of variable kinds of immunocytes in tumor microenvironment. The immunomodulation of leptin resistance is vital for the development of cancer. Up to now, the immunomodulation of leptin resistance has been found to act in many kinds of tumors. To elucidate its mechanism might prove effective in cancer diagnosis and prevention.关键词
瘦素/瘦素抵抗/免疫调节/肿瘤/低氧Key words
leptin/ leptin resistance/ immunomodulation/ neoplasms/ hypoxia分类
医药卫生引用本文复制引用
程欢欢,王华阳,曲迅..瘦素抵抗的免疫调节作用及其与肿瘤发生的关系[J].基础医学与临床,2012,(9):1099-1102,4.基金项目
国家自然科学基金(81072406,30872321) （81072406,30872321）
山东省自然科学基金(Y2008C02) （Y2008C02）
山东大学优秀研究生科研创新基金资助(yyx10126) （yyx10126）
