解放军医学杂志2012，Vol.37Issue(11)：1050-1053,4.
肾交感神经射频消融术对高血压犬去甲肾上腺素溢出率及交感神经活性的影响
Effects of renal sympathetic nerve radiofrequency ablation on norepinephrine spillover rate and sympathetic nerve activity in dogs with hypertension
余航 1杨成明 1李慧杰 1曾春雨 1方玉强 1何多芬 1张小群 1温春兰1
作者信息
- 1. 400042 重庆 第三军医大学大坪医院野战外科研究所心血管内科
- 折叠
摘要
Abstract
Objective To evaluate the validity and explore the mechanism of renal sympathetic denervation (RSD) in the treatment of dogs with hypertension reproduced by constriction of abdominal aorta. Methods The hypertension model was reproduced by constriction of abdominal aorta in 20 adult healthy dogs. These dogs were then randomly divided into the treatment group and control group (10 each). Renal sympathetic nerve radiofrequency ablation was done in treatment group 1 month after modeling. The foreleg blood pressure, sympathetic activity and norepinephrine overflow rate of dogs in two groups were detected before modeling, and 1, 2 and 3 months after modeling, and the trend of the change was also observed. Results One month after modeling, the systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) were elevated significantly in control group (146.7 ± 21.0, 89.0 ± 12.7 and 108.3 ± 14.9mmHg) compared with those before modeling (119.5 ± 13.2, 76.5 ± 7.8 and 90.9 ± 8mrnHg, P<0.05). The renal sympathetic activity impulse and norepinephrine spillover rate were also enhanced significantly (P<0.05). The renal sympathetic nerve activity obviously decreased in the treatment group after the operation, and then increased 2 months after the ablation. The norepinephrine spillover rate in treatment group increased significantly 1 month after modeling (P<0.05), and decreased after ablation, and it lasted to the end of the experiment (P<0.05). One and two months after ablation, the norepinephrine spillover rate was lower in treatment group than in control group (P<0.05). Conclusion Renal sympathetic nerve radiofrequency ablation significantly inhibits the elevation of norepinephrine spillover rate and sympathetic nerve activity in dogs with hypertension.关键词
高血压/导管消融术/去甲肾上腺素/交感神经系统Key words
hypertension/ catheter ablation/ norepinephrine/ sympathetic nervous system
分类
医药卫生引用本文复制引用
余航,杨成明,李慧杰,曾春雨,方玉强,何多芬,张小群,温春兰..肾交感神经射频消融术对高血压犬去甲肾上腺素溢出率及交感神经活性的影响[J].解放军医学杂志,2012,37(11):1050-1053,4.
