解放军医学杂志2012，Vol.37Issue(11)：1069-1072,4.
职业锰暴露人群外周血铁代谢的变化观察
Effects of manganese exposure on iron metabolism in peripheral blood of exposed population
摘要
Abstract
Objectives To investigate the adverse effect of manganese exposure on the iron metabolism in peripheral blood of professionally exposed workers. Methods The manganese in air was collected using personal air sampler, and the time weighted average (TWA) concentration of exposure to manganese was then calculated. The subjects were divided into exposure group (n=SS) and control group (n=S0) based on the exposure doses they received. The concentrations of iron and manganese in the plasma and blood cells of the subjects were determined using flame atomic absorption detector and graphite furnace atomic absorption detector. Serum ferritin, transferring transferrin receptor and total iron binding capacity were determined using enzyme linked immunosorbent assay. Results The manganese contents in both plasma and blood cells were much higher in exposure group than in control group (P<0.0l). Compared with the control group, the iron contents in both plasma and blood cells, serum transferrin receptor and total iron binding capacity decreased (P<0.0l), while serum ferrin and transferrin increased (P<0.05 and P<0.0l) in workers with professional manganese exposure less than S years. While in those workers undergoing manganese exposure equal to or longer than 5 years, the iron content of plasma and serum transferring receptor decreased (P<0.05 and P<0.0l), and serum transferrin increased (P<0.0l), The blood cell manganese content was lower (P<0.05) and blood cell iron level higher (P<0.05) in workers with professional manganese exposure equal to or longer than 5 years than in those workers with manganese exposure less than 5 years. However, no difference was found in other indexes between two groups (P>0.05). It was revealed by linear correlation analysis that no linear correlation existed between the professional exposure time and manganese and iron contents in both plasma and blood cells, serum ferrin, transferring transferring receptor and total iron binding capacity (P>0.05). Conclusion The long-term exposure to high dose manganese may result in an imbalance of iron metabolism in the peripheral blood in exposed population, manifesting a decrease of plasma iron and serum transferrin receptors, and an increase of serum transferrin.关键词
锰/职业暴露/铁代谢障碍Key words
manganese/ occupational exposure/ iron metabolism disorders分类
医药卫生引用本文复制引用
熊云刚,申旭波,姜慧,贾飞飞,范奇元,邹焰..职业锰暴露人群外周血铁代谢的变化观察[J].解放军医学杂志,2012,37(11):1069-1072,4.基金项目
国家自然科学基金(30760209) （30760209）
贵州省国际科技合作重点项目(400116) （400116）
遵义市科技局科研合作项目(遵市科合社字[2008]6号) （遵市科合社字[2008]6号）
