解放军医学杂志2012，Vol.37Issue(12)：1125-1129,5.
感冒一号汤剂治疗普通感冒的疗效评价:随机平行对照研究
A randomized controlled trial on therapeutic efficacy and safety of No.1 Decoction for common cold
摘要
Abstract
Objective To assess therapeutic efficacy and safety of No. 1 Decoction for common cold in patients. Methods A randomized controlled trial was conducted to study 225 male military officers and soldiers who were suffering from common cold, while 6 of them who showed positive results in the colloidal gold immunochromatography assay (GICA) for detecting Flu A/ B or LP were excluded. The remaining 219 patients were randomly allocated either to receive No. 1 Decoction (study group, n=lll) or Ganmao Qingre Keli (control group, n=108) for 3 days. Grading quantization form for symptoms of common cold were filled for all patients. Clinical response rate, significant response rate and complete cure rate were analyzed. Adverse events were also observed and recorded. Results In this trial, 2 patients in test group and 1 in study group were lost in follow-up, 13 cases with incomplete data were excluded (5 in study group, 8 in control group). 219 patients were included in FAS set and SS set, and data of 203 cases were observed in the PP set. In FAS set, the study group had a higher clinical recovery rate and effective rate than the control group (14.41% vs 12.96%, P=0.755; 72.97% vs 64.81%, P=0.192), and had a lower significant effective rate than control group (36.94% vs 43.52%, P=0.32l). The 95% confidence interval for the difference between the effective rates of study group and control group was (-4.06% -20.38%, Δ =-10%), suggesting No.I Decoction might be as effective as Ganmao Qingre Keli. The results of PP set were similar to that of FAS set. Conclusion No. 1 Decoction is a safe and effective drug for common cold.关键词
普通感冒/随机对照试验/感冒一号汤剂Key words
common cold/ randomized controlled trials/ No. 1 Decoction for common cold分类
医药卫生引用本文复制引用
霍晓荣,陈杭薇,李雪辉,尤兰华,朱赛楠..感冒一号汤剂治疗普通感冒的疗效评价:随机平行对照研究[J].解放军医学杂志,2012,37(12):1125-1129,5.基金项目
全军"十一五"医学科研攻关课题(06G026) （06G026）
