实用临床医药杂志2012，Vol.16Issue(21)：22-24,3.
非小细胞肺癌患者呼出气冷凝液VEGF检测的临床意义
Clinical significance of detecting VEGF in exhaled breath condensate of patients with lung cancer
摘要
Abstract
Objective To study the clinical significance of measuring VEGF in exhaled breath condensate(EBC) of patients with non-small cell lung cancer(NSCLC). Methods Forty patients with confirmed NSCLC by pathology were enrolled in the study. Among them, 20 patients had stable chronic obstructive pulmonary disease (COPD) and the rest 20 were healthy subjects. Serum samples were also collected from the three groups. VEGF levels were measured in EBC and serum of all the subjects under study were applied with enzyme linked immunosorbent assay (ELISA) method. Results ① VEGF levels in EBC and serum were higher in NSCLC group[ (11. 7±6. 1) pg/mL, (310. 5 + 23. 9) pg/mL] than those in COPD patients[(6. 3 ± 4. 9) pg/mL, (217.1 ±14. 7) pg/mL] and healthy controls[(3. 6 ± 1. 2) pg/mL, (162.5 + 16.5) pg/mL]; ② The VEGF levels in EBC and serum of NSCLC group had a positive correlation with the tumor stages and lymph node metastasis, but were not related to the tumor type, gender, age and smoking history. Conclusion The detection of VEGF levels in EBC is beneficial to the early diagnosis, progress and prognosis of lung cancer.关键词
血管内皮生长因子/呼出气冷凝液/非小细胞肺癌Key words
vascular endothelial growth factor (VEGF) /exhaled breath condensate (EBC)/non-small cell lung cancer分类
医药卫生引用本文复制引用
姜剑松..非小细胞肺癌患者呼出气冷凝液VEGF检测的临床意义[J].实用临床医药杂志,2012,16(21):22-24,3.基金项目
中国高校医学期刊临床专项资金(11220167) （11220167）
