实用临床医药杂志2012，Vol.16Issue(21)：28-30,3.
辛伐他汀对高血压合并颈动脉硬化患者肱踝脉搏波传导速度及颈动脉内膜中层厚度的影响
Impact of simvastatin on brachial-ankle pulse wave velocity and carotid intima-media thickness in hypertension patients complicated by carotid atherosclerosis
摘要
Abstract
Objective To explore the impact of simvastatin on brachial-ankle pulse wave (baPWV) velocity and carotid intima-media thickness (IMT)in hypertension patients combined with carotid atherosclerosis. Methods A total of 120 hypertension patients complicated by atherosclerosis were divided into simvastatin group ( n = 60) and control group ( n — 60 ). Both groups sustained original plan on hypertension, and the treatment group received additional simvastatin therapy on original plan. The changing of blood lipid, IMT, baPWV pretherapy and postther-aphy were observed. Results Compared with pretherapy, TC, TG and LDL-C level were significantly decreased in simvastatin group (P < 0.01), and HDL level was significantly increased. After treatment, TC, TG and LDL-C level were significantly lower in simvastatin group than in the control group (P<0.01) . HDL level in simvastatin group was higher than in the control group (P< 0.01). Compared with pretherapy, baPWV level decreased in both groups, and IMT level significantly lessened in simvastatin group (P<0.01). Compared with posttherapy control group, IMT and bPWV level of simvastatin increased significantly (P<0. 01). Conclusion Lessening IMT level and baPWV to prevent atherosclerosis and simvastatin can significantly decrease the blood lipid level.关键词
辛伐他汀/高血压/颈动脉硬化/肱踝脉搏波传导速度/颈动脉内膜中层厚度Key words
simvastatin/hypertension/athrosclerosis/brachial-ankle pulse wave/carotid intima-media thickness分类
医药卫生引用本文复制引用
王俊..辛伐他汀对高血压合并颈动脉硬化患者肱踝脉搏波传导速度及颈动脉内膜中层厚度的影响[J].实用临床医药杂志,2012,16(21):28-30,3.基金项目
中国高校医学期刊临床专项资金(11220221) （11220221）
