实用临床医药杂志2012，Vol.16Issue(21)：31-33,44,4.
慢性乙型肝炎中医证型分布与免疫学指标、HBV-DNA定量关系的研究
Quantitative relationship between TCM syndrome distribution and immunological parameters and HBV-DNA in chronic hepatitis B
摘要
Abstract
Objective To investigate the relationship between TCM syndrome distribution laws and certificate of chronic hepatitis B-type and laboratory indicators. Methods A total of 300 eligible subjects were enrolled in the study. The HBV-DNA, T cell subsets and other laboratory parameters were observed. Results Stagnation and spleen deficiency is the most common type. T-cell immune function in the peripheral blood had significant difference between different syndrome types. The HBV-DNA high copy accounting for copy number of patients: liver and spleen deficiency (41.1%)>damp heat resistance type (22. 6% )>blood stasis type (21. 2% )> liver-kidney (8. 5 %) >spleen and kidney yang (5.6 %). With the increase of the virus copy number, CD4 T cell percentages and CD4 + /CDg+ ratio decreased. CDg + T cell percentage and HBV-DNA copy number increased proportionally. CD3+ and CD4+ T cell percentage between groups showed no significant difference DNA negative group. CDg+ T cell percentage was significantly lower than the DNA-posi-tive group. Conclusion TCM syndromes of chronic hepatitis B with a certain regularity. Peripheral blood lymphocyte immune function test results (Eg, of CD3+ , of CD4 + , CDg+ and of CD4 + / CDg+ ), HBV-DNA load can be used as the objective reference of the type of clinical syndrome.关键词
慢性乙型肝炎/辨证分型/细胞免疫/HBV-DNA定量Key words
chronic hepatitis B/syndrome type/cellular immunity/quantitative HBV-DNA分类
医药卫生引用本文复制引用
田广俊,池晓玲,谈博,蔡东林..慢性乙型肝炎中医证型分布与免疫学指标、HBV-DNA定量关系的研究[J].实用临床医药杂志,2012,16(21):31-33,44,4.基金项目
广东省中医药管理局课题(2009390) （2009390）
