实用临床医药杂志2012，Vol.16Issue(21)：97-98,2.
罗格列酮对2型糖尿病患者血浆成纤维细胞生长因子-21及胰岛素敏感性的影响
Effect of rosiglitazone on FGF-21 and insulin sensitivity in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the effect of rosiglitazone on FGF-21 and insulin sensitivity in patients with type 2 diabetes mellitus. Methods Forty patients with T2DM (treatment group) received oral rosiglitazone, 4 mg, 1 times/d, for 12 weeks. Another 35 healthy patients were assigned to control group. Before and after treatment, FBG, 2hBG, HbAlC, Fins, 2hlns, lipids, FGF-21 and other biochemical markers were observed. The GIR in the treatment group before and after treatment was observed. Results Before treatment, FBG, 2hBG, HbAlC, Fins, TC, LDL-C, FGF-21 levels were significantly higher in the treatment group than in the control group (P<0.01). In the treatment group, FBG, 2hBG, HbAlC, Fins, TG, TC, LDL-C, FGF -21 levels were significantly lower than before treatment (P< 0.01). After treatment, the GIR was significantly higher than that before treatment (P<0.01). Conclusion Rosiglitazone can significantly reduce the plasma of patients with type 2 diabetes, FGF-21 levels, and improve insulin sensitivity.关键词
罗格列酮/2型糖尿病/成纤维细胞生长因子-21Key words
rosiglitazone/type 2 diabetes mellitus/fibroblast growth factor-21分类
医药卫生引用本文复制引用
冒群..罗格列酮对2型糖尿病患者血浆成纤维细胞生长因子-21及胰岛素敏感性的影响[J].实用临床医药杂志,2012,16(21):97-98,2.基金项目
中国高校医学期刊临床专项资金(11220161) （11220161）
