昆虫学报2012，Vol.55Issue(11)：1315-1321,7.
昆虫海藻糖酶的基因特性及功能研究进展
Progress in gene features and functions of insect trehalases
摘要
Abstract
Trehalase ( Treh) plays key roles in energy metabolism and is the first enzyme in chitin biosynthesis pathway of insect. Expression profile and enzyme activity of Treh are related to many important physiological processes of insects, including development, molting, metamorphosis and reproduction. To date, two kinds of Treh genes have been successfully cloned in different insect species, and it has been found that the gene family of insect Trehs is composed of multiple members. Most proteins encoded by Treh genes contain signal peptides in their leader regions, and partial proteins possess 1 or 2 transmembrane domains, based on which, Trehs are divided into two types, named the soluble (Trehl) and membrane-bound ( Treh2 ) Trehs, respectively. In addition, there are two specific motifs ("PGGRFREFYYWDSY" and "QWDYPNAWPP") in Treh2. The core function of Treh is to degrade the extra and intercellular trehalose into glucose in order to provide energy for insects, by participating in insect chitin biosynthesis to regulate chitin synthesis in the cuticle and midgut or cooperating with hormone to control the concentrations of trehalose and glucose dynamically in insects, so in this way insect cells would be effectively protected in adverse environment and their capacities of stress resistance be significantly improved. In view of the important roles it plays in energy metabolism and chitin biosynthesis, trehalase has been a potential novel target for insect pest control. The functional research of trehalase and development of its inhibitors may contribute to the biological control of insect pests in the future.关键词
海藻糖酶/基因克隆/几丁质合成/能量代谢/海藻糖酶抑制剂Key words
Trehalase/ gene cloning/ chitin synthesis/ energy metabolism/ trehalase inhibitors分类
生物科学引用本文复制引用
唐斌,魏苹,陈洁,王世贵,张文庆..昆虫海藻糖酶的基因特性及功能研究进展[J].昆虫学报,2012,55(11):1315-1321,7.基金项目
国家自然科学基金项目(31071731,31000880) （31071731,31000880）
杭州师范大学优秀中青年教师支持计划(JTAS2011-01-031) （JTAS2011-01-031）
中山大学有害生物控制与资源利用国家重点实验室访问学者基金资助项目(SKLBC12F01) （SKLBC12F01）
