昆明医科大学学报2012，Vol.33Issue(11)：35-37,3.
蛇毒抗菌肽OH-CATH在血浆环境中对大肠杆菌的抗菌作用
The Antibacterial Effects of Snake Venom Antimicrobial Peptide OH-CATH on E.coli in the Presence of Plasma
摘要
Abstract
Objective To research whether venom antimicrobial peptide OH-CATH will lose anti-bacterial activity in plasma environment. Method We added different doses of snake venom antimicrobial peptide OH-CATH in LB with (Group B) and without plasma (Group A) to get final concentration of antimicrobial peptides including 0 μg/mL, 1 μg/mL, 2 μg/mL, 4 μg/mL, 8 μLg/mL, 16 μg/mL and 32 μg/mL, and added E.coli ATCC25922 in each EP which were then cultured, and the OD values were detected. Results There was no significant differences in OD value of the corresponding point between group A and B (P>0.05 ). The MIC of snake venom OH-CATH antimicrobial peptides was at the range of 4 ~ 8 μg/m L. Conclusion Venom antibacterial peptide OH-CATH will not be rapidly degraded in the plasma environment and be inactivated, and has good antibacterial effect on Ecoli.关键词
蛇毒抗菌肽OH-CATH/大肠杆菌/血浆Key words
Snake venom antimicrobial peptide OH-CATH/ E.coli/ Plasm分类
生物科学引用本文复制引用
高振华,李思熳,申吉泓..蛇毒抗菌肽OH-CATH在血浆环境中对大肠杆菌的抗菌作用[J].昆明医科大学学报,2012,33(11):35-37,3.基金项目
云南省应用基础研究基金资助项目(2011FZ117) （2011FZ117）
