临床神经病学杂志2012，Vol.25Issue(5)：325-327,3.
磁共振波谱对原发性癫痫患者海马病变的诊断价值
Diagnostic value of magnetic resonance proton spectrum examination on hippocampus lesions in patients with primary epilepsy
武强 1王鹰 2游曼洁 1廖光昊 1濮捷 1程鹤1
作者信息
- 1. 430070 广州军区武汉总医院神经内科
- 2. 430070 广州军区武汉总医院放射科
- 折叠
摘要
Abstract
Objective To explore the diagnostic value of magnetic resonance proton spectrum (MRS) on hippocampus lesions in patients with primary epilepsy. Methods Thirty eight patients with primary epilepsy (epilepsy group) and 30 healthy volunteers (normal control group) were examined by EEG, MRI and MRS. The metabolic products of N-acetylaspartate (NAA) , creatine (Cr) and choline (Cho) were quantitatively analyzed through MRS on bilateral hippocampus. Results There was no abnormal in normal control group by EEG, MRI and MRS. In epilepsy group, there were 30 cases (78.9%) found epileptiform discharges by EEG; there were 15 cases (39. 5%) found abnormal in hippocampus by MRI, including 10 cases of bilateral abnormality and 5 cases of unilateral abnormality; there were 35 cases (92. 1 %) found abnormal in hippocampus by MRS, including 30 cases of bilateral abnormality and 5 cases of unilateral abnormality. The values of Cho/Cr and Cho/NAA of the abnormal side hippocampus in the epilepsy group were significantly higher than those in the normal side of hippocampus and the normal control group (all P < 0. 001) , and the value of NAA/(Cho + Cr) of the abnormal side hippocampus in the epilepsy group was significantly lower than that in the normal side of hippocampus and the normal control group (all P <0. 001). The value of NAA/(Cho + Cr)of the head of hippocampus was significantly lower than that in the body and the tail of hippocampus in the abnormal side (all P < 0. 001). Conclusion MRS can increase the positive rate of hippocampus lesions in patients with primary epilepsy, and can show the biochemical changes of the hippocampus, which has a high diagnosis value on primary epilepsy.关键词
原发性癫痫/磁共振波谱/海马Key words
primary epilepsy/ magnetic resonance proton spectrum/ hippocampus分类
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武强,王鹰,游曼洁,廖光昊,濮捷,程鹤..磁共振波谱对原发性癫痫患者海马病变的诊断价值[J].临床神经病学杂志,2012,25(5):325-327,3.
