临床神经病学杂志2012，Vol.25Issue(6)：425-427,3.
依达拉奉对急性脑梗死患者血清血管内皮生长因子和肿瘤坏死因子水平的影响
Effect of Edaravone on the levels of serum vascular endothelial growth factor and tumor necrosis factor-α in patients with acute cerebral infarction
陈景红 1李娜 1孙素娟 1高俊淑 1赵景茹1
作者信息
- 1. 050051石家庄,河北省人民医院神经内科
- 折叠
摘要
Abstract
Objective To investigate Edaravone on the levels of serum vascular endothelial growth factor(VEGF) and tumor necrosis factor (TNF) -α in patients with acute cerebral infarction (ACI). Methods Eighty-four ACI patients were randomly divided into the Edaravone group and control group. On the basic of ACI routine treatment, Edaravone group received Edaravone 60 mg/d intravenous drip for 14 d. Pre and 14 d, 28 d post treatment, the neurological deficits of all the patients were evaluated by Scandinavian Stroke Scale (SSS) ; the levels of serum VEGF and TNF-ot were detected at 3 d,7 d and 14 d after onset, respectively by enzyme-linked immunosorbent assay. Results Compared with pre treatment, SSS of post treatment in the two groups were significantly decreased (P ＜ 0. 05 -0. 01), meanwhile, which in Edaravone group at each time point were significantly decrased than control group(all P ＜ 0. 05). The levels of serum VEGF and TNF-α at each time point in the two groups were significantly higher than normal values, and which at 7 d after onset were significantly higher than 3 d and 14 d after onset (all P ＜ 0. 05). The levels of serum VEGF at each time points in Edaravone group were significantly lower than the control group (all P ＜ 0. 01). The levels of serum TNF-α at each time point between the two groups were no statistical significance. Conclusion Edaravone can obviously decrease the levels of serum VEGF in ACI patients and reduce the brain damage caused free radical after ACI.关键词
依达拉奉/急性脑梗死/血管内皮生长因子/肿瘤坏死因子Key words
Edaravone/ acute cerebral infarction/ vascular endothelial growth factor/ tumor necrosis factor分类
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陈景红,李娜,孙素娟,高俊淑,赵景茹..依达拉奉对急性脑梗死患者血清血管内皮生长因子和肿瘤坏死因子水平的影响[J].临床神经病学杂志,2012,25(6):425-427,3.
