临床神经病学杂志2012，Vol.25Issue(6)：438-439,2.
依达拉奉对Alzheimer病模型大鼠认知功能及海马内乙酰胆碱含量的影响
Effect of Edaravone on cognitive function and level of acetylcholine in hippocampus in rat models of Alzheimer disease
贺睿 1方敏 2贺峰3
作者信息
- 1. 271219泰安,新汶矿业集团中心医院医保科
- 2. 271219泰安,新汶矿业集团中心医院神经内二科
- 3. 临沂市人民医院神经内科
- 折叠
摘要
Abstract
Objective To explore the effect of Edaravone (EDA) on cognitive function and level of acetylcholine (Ach) in hippocampus in rat models of Alzheimer disease (AD). Method Thirty rats were randomly divided into sham operated group, AD group and EDA group. Amyloid-β-protein (Aβ) 1-40 was injecting into the rat's hippocampus of AD and EDA groups to establish AD model. Then, EDA was intraperitoneally injected in EDA group for 2 weeks. After 5 weeks of the operation, the cognitive function of rats in each group was measured by Morris water maze test; and the level of Ach in hippocampus was detected by high performance liquid chromatography. Results Compared with sham operated group, the escape latencies in EDA and AD groups were obviously prolonged, purpose quadrant retention times were significantly shorter, crossing circle times were significantly increased (P ＜ 0. 05 -0.01). Compared with AD group, the escape latency in EDA group was significantly shorter, purpose quadrant retention time was significantly shortened, crossing circle times was significantly increased (P ＜ 0. 05 -0.01). Compared with sham operated group, the levels of Ach in hippocampus in EDA and AD groups were obviously decreased (all P ＜ 0. 01) ; but which in EDA group was obviously increased than AD group (P ＜0. 01). Conclusion EDA can improve cognitive function in rat models of AD by increase the level of Ach in hippocampus.关键词
依达拉奉/Alzheimer病/认知功能/乙酰胆碱Key words
Edaravone/ Alzheimer disease/ cognitive function/ acelylcholine分类
医药卫生引用本文复制引用
贺睿,方敏,贺峰..依达拉奉对Alzheimer病模型大鼠认知功能及海马内乙酰胆碱含量的影响[J].临床神经病学杂志,2012,25(6):438-439,2.
