临床误诊误治2012，Vol.25Issue(12)：52-54,3.DOI:10.3969/j.issn.1002-3429.2012.12.021
血管内皮生长因子C水平对膀胱癌诊断和预后评估的临床价值
Clinical Significance of the Level of Vascular Endothelial Growth Factor-C in Diagnosis and Prognosis of Patients with Bladder Cancer
摘要
Abstract
Objective To explore the relationship between the level of vascular endothelial growth factor-C with the development , recurrence, metastasis and prognosis of bladder cancer. Methods Levels of serum VEGF-C were detected and compared between 71 patients with bladder cancer by pathology diagnosis (bladder cancer group) and 50 healthy controls (control group). Results The serum level of VEGF-C in bladder cancer group (1.4~42.2 μg/L) was significantly higher than that of in control group (0.2 ~ 12.6 μg/L) (P<0.01). The serum level of VEGF-C in bladder cancer group was related to lymph nodes metastasis, lymphovascular invasion, vascular infiltrating and recurrence, and the differences were statistically significant (P <0.05) ; but the serum level was not related to clinical stages and pathological stages (P >0.05). Sensitivity and specificity of serum VEGF-C in diagnosis of bladder cancer were 81.7% and 72.0% respectively. The survival rate in patients with high VEGF-C levels was significantly lower than those with low VEGF-C levels in bladder cancer patients (P < 0. 05). Conclusion Detection of serum VEGF-C is a useful marker in diagnosis and prognosis of bladder cancer.关键词
血管内皮生长因子C/膀胱癌/诊断/预后Key words
Vascular endothelial growth factor-C/ Bladder cancer/ Diagnosis/ Prognosis分类
医药卫生引用本文复制引用
梁彬,郭政东,李云慧..血管内皮生长因子C水平对膀胱癌诊断和预后评估的临床价值[J].临床误诊误治,2012,25(12):52-54,3.基金项目
辽宁省自然科学基金资助项目(201102279) （201102279）
