临床与实验病理学杂志2012，Vol.28Issue(11)：1198-1201,4.
乳腺原发癌和淋巴结转移癌中Hedgehog信号蛋白的表达及意义
Expression and significance of Hedgehog signaling proteins in primary breast cancer and matched lymph node metastases
摘要
Abstract
Purpose To investigate the associated protein expression and significance of Hedgehog signaling pathway in primary breast cancer and matched lymph node metastases. Methods The protein expressions of Shh, Ptch, Smo and Gli-1 were detected by immu-nohistochemistry in a series of 57 human invasive breast cancer and matched lymph node metastases, and 35 cases of normal breast ductal epithelial tissues. Results The expression of Shh, Ptch, Smo and Gli-1 in normal breast ductal epithelial tissues were completely absent or rare. The positive rates of Shh, Ptch, Smo and Gli-1 in primary breast cancer were 91. 2% ( 52/57 ), 86% ( 49/ 57 ), 91. 2% ( 52/57 ) and 71. 9% ( 41/57 ), the positive rates in the matched lymph node metastases were 82. 5% ( 47/52 ), 91. 2% ( 52/57 ), 75. 4% ( 43/ 57 ) and 22. 8% ( 3/57 ). Shh and Ptch expression had no differences in primary breast cancer and matched lymph node metastases ( P >0. 05 ). While Smo and Gli-1 expression had differences in primary breast cancer and matched lymph node metastases ( P <0. 05 and P <0. 01 ) and Smo expression was significantly correlated with Gli-1 both primary breast cancer and matched lymph node metastases ( P <0. 01 ). Conclusion The expression of Shh and Ptch protein in primary breast cancer and lymph node metastases are in high level and show the consistency of expression. Smo and Gli-1 expression in primary cancer are significantly higher than those in the lymph node metastases. Especially, the high expression of Gli-1 protein in primary breast cancer may play an important role in the invasion and lymph node metastases of the human invasive breast cancer.关键词
乳腺肿瘤/淋巴结转移/Hedgehog信号通路Key words
breast neoplasms/ lymph node metastases/ Hedgehog signaling pathway分类
医药卫生引用本文复制引用
徐珊珊,韩玉贞,马文浩,朱玉红..乳腺原发癌和淋巴结转移癌中Hedgehog信号蛋白的表达及意义[J].临床与实验病理学杂志,2012,28(11):1198-1201,4.基金项目
山东省自然科学基金资助(ZR2010HM096) （ZR2010HM096）
