国际眼科杂志2012，Vol.12Issue(12)：2256-2260,5.DOI:10.3980/j.issn.1672-5123.2012.12.03
补肾活血中药对大鼠慢性高眼压模型初级视皮质尼氏小体损害的影响
Influence of Bushenhuoxue on primary visual cortex's Nissl bodies damage in rat model of chronic elevated intraocular pressure
摘要
Abstract
AIM: To observe the effect of Traditional Chinese Medicine (TCM) of Bushenhuoxue on primary visual cortex(PVC)'s Nissl bodies damage in rat model of chronic elevated intraocular pressure (EIOP), and explore the mechanism of it initially.cauterizing 3 episcleral vessels, then 30 rats were divided into 3 groups randomly: control group, model group, and treatment group. After given drugs or normal saline for 8 weeks, the rats were put to death. The effect of intraocular pressure (IOP), content of Nissl bodies and ultrastructure of neuron cell in the PVC was observed.modle obviously, there was significant difference compared with preoperative (P<0.01). Semi-quantitative pathological analysis showed that Nissl body of total area in the model group was(34941±8482 1)S/μm2,mean optical density was (152.8±27.97), integrated optical density was (11993±3084.8), compared with the control group, total area was (55742±6348.1)S/μm2,mean optical density was (304.04±100.1),integrated optical density was (18219±3548.9), there were statistically differences (all P<0.05). There were statistically difference in Nissl body of total area, mean optical density and integrated optical density between model group and treatment group, total area was (46406±5989.3)S/μm2,mean optical density was (251.05±77.41),integrated optical density was (16899±4040.6, all P<0.05).chronic EIOP by enhancing expression of Nissl body, improving ultrastructure of neuron cell.关键词
青光眼/大鼠慢性高眼压模型/补肾活血中药/初级视皮质/尼氏小体/神经元细胞超微结构Key words
glaucoma/rat model of chronic elevated intraocular pressure/TCM of Bushenhuoxue/primary visual cortex/Nissl bodies/ultrastructure of neuron cell引用本文复制引用
李翔,郭红建,文晓霞,谢钊,谢学军,路雪婧,王毅,张静..补肾活血中药对大鼠慢性高眼压模型初级视皮质尼氏小体损害的影响 [J].国际眼科杂志,2012,12(12):2256-2260,5.基金项目
Key Projects of Sichuan Provincial Education Office,China (No.10ZA096) （No.10ZA096）
中国四川省教育厅2010年重点项目(No.10EA09) （No.10EA09）
