四川大学学报（自然科学版）2012，Vol.49Issue(6)：1342-1348,7.DOI:10.3969/j.issn.0490-6756.2012.06.031
水稻中Intronic MicroRNA与其宿主基因功能关系分析
Analysis of functional relationship between rice intronic MicroRNA and their host Genes
摘要
Abstract
Based on rice genome annotations, 437 known pre-miRNAs in rice were analyzed. As a result, 98 pre-miRNAs (- 22%) overlapped with protein coding gene and 69 (~16%) of them located in intronic regions, namely intronic microRNAs (in-miRNAs). Through Gene Ontology (GO) enrichment a-nalysis of target genes of these in-miRNAs, it is suggested that in-miRNAs significantly down-regulated genes involved in biological processes such as protein amino acid phosphorylation, DNA integration, proteolysis, homoiothermy and defense response. Finally, integration function analysis of both host genes and target genes revealed that targets genes of 4 in-miRNAs could participate in biological processes in which host genes involved. We conclude in-miRNAs could play a synergistic or antagonistic role to repress or promote their host genes in common biological processes shared by target genes and host genes.关键词
Intronic microRNA/宿主基因/功能关系/GO富集分析/水稻Key words
intronic microRNA,host hene,functional relationship,GO enrichment analysis,rice分类
生物科学引用本文复制引用
童永鳌,王胜华..水稻中Intronic MicroRNA与其宿主基因功能关系分析[J].四川大学学报（自然科学版）,2012,49(6):1342-1348,7.基金项目
国家自然科学基金(31070276) （31070276）
