四川中医2012，Vol.30Issue(10)：33-35,3.
脑卒中后大鼠行为学的动态变化及中药颐脑解郁方的干预作用
Dynamic Changes of Ethology and Interventional Effects of Chinese Medicinal, Yi' nao Jieyu Formula, in Rats with Post Stroke
摘要
Abstract
Objective: To observe the dynamic behavior changes and early intervention effects of Yi' nao Jieyu Formula after stroke in rats. Methods; Scoring by the Open-Field behavior in male Wistar rats were randomly divided into normal group, sham-operation group, MCI group, treatment group, control group, PSD group and VD group. Model was prepared by in vitro injection of the same germ-line microemboli from the external carotid artery of 0. 3ml of allogeneic clot; sham operation group were injected the same dose of saline and intragastrically administrated with distilled water, Traditional Chinese Medicine group and western group were respectively administrated of four weeks with Yinao Jieyu Formula and Nimodipine after model prepared; PSD model was prepared by chronic unpredictable mild stress plus solitary housed from 7d to 21 d after operation; VD group were collected by the water maze filtered on 28"1 day after operation. Shuttle box active avoidance response experiment was respectively done on the 1", 2 and 4 week after success of model copying, and recording the initiative to escape ( AAR) , the number of passive avoidance (PAR) , the number of electric shock time, and statistically analyzing. Results; The frequency of PAR and AAR were the lowest in VD group, the frequency of PAR and AAR of Chinese medicine group were lower than the sham-operation groups, the frequency of AAR and PAR had significant differences (P<0. 05, P<0. 01) between the two groups. Conclusion; Yi ' nao Jieyu Formula can improve learning and memory function, and it' s benefit to recovery of stroke cognitive function in rats.关键词
脑卒中/大鼠/行为学/颐脑解郁方/动态变化Key words
Stroke Rats Ethology Yi'nao Jieyu Formula Dynamic changes分类
医药卫生引用本文复制引用
王戈,唐启盛,李小黎,李冬梅..脑卒中后大鼠行为学的动态变化及中药颐脑解郁方的干预作用[J].四川中医,2012,30(10):33-35,3.基金项目
国家自然科学基金资助项目(No.30973740),北京中医药大学自主选题项目 （No.30973740）
