四川中医2012，Vol.30Issue(10)：41-44,4.
熊珍膏对大鼠CRP及TNF-α的调节作用及对皮肤创面愈合影响的实验研究
Accommodation of Xiongzhen Ointment on CRP, TNF-α and the Effects on Skin Wound Healing of Rats
摘要
Abstract
Objective: To observe the effect of Xiongzhen Ointment in micro-vessels and number of fibroblasts in rat cutaneous incised wound healing and investigate the mechanism of accelerating the rat back wound healing. Methods; After setting up the model, the rats were randomly assigned to 4 groups: model group, bFGF-ESSEX group (western medicine control group) , Xiongzhen Ointment group, bFGF-ESSEX + Xiongzhen Ointment group. The medicine were attach to the skin twice a day. After setting up models for 3, 7and 14 days, the rats were killed to perform immune-histochemistry study. S-P method of immune-his-tochemistry was used to detect CD34, number of fibroblasts of the local granulation tissue. We used image analysis equipment and computer software to analyze the image of each group. The data were expressed as Mean+SD and was analyzed by SPSS 18. 0. Results; The number intensity of granulation tissue were significantly better in Xiongzhen Ointment group than model group in all three time points ( P<0. 01) . The improvement of number of fibroblasts was significantly better in Xiongzhen ointment group than model group in all three time points. Conclusion: The Xiongzhen Ointment can accelerate the healing of skin trauma of the rats and improve the quality of healing. This may be related to microvessels improvement and fibroblasts numbers of granulation tissue.关键词
熊珍膏/创面愈合/C反应蛋白/肿瘤坏死因子-αKey words
Xiongzhen Ointment Skin wound healing CRP TNF-a分类
医药卫生引用本文复制引用
陈敏,黄德铨,杜勇军,康健,宋英,吴纯洁,曹吉勋..熊珍膏对大鼠CRP及TNF-α的调节作用及对皮肤创面愈合影响的实验研究[J].四川中医,2012,30(10):41-44,4.基金项目
四川省科技支撑计划:熊珍制剂二次开发研究(编号2011SZ0249) （编号2011SZ0249）
成都中医药大学附属医院科技发展计划重点项目(编号:2010-D-YY-04) （编号:2010-D-YY-04）
