同济大学学报（医学版）2012，Vol.33Issue(6)：27-30,4.DOI:10.3969/j.issn.1008-0392.2012.06.007
睾酮水平的变化对雄性大鼠血管内皮功能的影响
Effects of testosterone levels on vascular endothelial function in castrated male rats
谈世进 1王艳妮 1丁在咸2
作者信息
- 1. 上海交通大学附属第六人民医院老年病科,上海200233
- 2. 上海交通大学附属第六人民医院动物实验中心,上海200233
- 折叠
摘要
Abstract
Objective To investigate the effects of testosterone levels on vascular endothelial function in castrated male rats. Methods Thirty male Wistar rats were randomized into 3 groups: rats underwent sham operation (Sham group, n = 10), rats were castrated (Cas group, n = 10) and rats were castrated and supplemented with testosterone 2 mg/kg (TC group 2 d, n = 10). Blood concentrations of testosterone, nitric oxide (NO), endothelin-1 (ET-1) were measured after 8 weeks. Results Compared with the sham group, the plasma testosterone concentration in Cas group was significantly lower (P < 0.05), and that in Tc group was not significantly changed (P > 0.05); plasma NO level in Cas group was significantly lower(P <0.05), and no change in TC group(P > 0. 05); plasma ET-1 content in Cas was significantly higher(P <0. 05), and no significant change in TC group (P > 0.05). Compared with Cas group, plasma testosterone and NO concentrations were significantly increased; whereas plasma ET-1 level was reduced in TC group( P <0.05). Conclusion Change of testosterone levels can affect the vascular endothelial function in castrated male rats. Testosterone deficiency results in vascular endothelial damage, followed by reduced NO and increased ET-1.关键词
睾酮/血管内皮细胞/一氧化氮/内皮素-1Key words
testosterone/ vascular endothelial cell/ nitric oxide/ endothelin-1分类
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谈世进,王艳妮,丁在咸..睾酮水平的变化对雄性大鼠血管内皮功能的影响[J].同济大学学报（医学版）,2012,33(6):27-30,4.
