实用医学杂志2012，Vol.28Issue(11)：1785-1787,3.DOI:10.3969/j.issn.1006-5725.2012.11.013
趋化因子受体5基因启动子单核苷酸多态性与HIV易感性关系的Meta分析
Meta analysis on the association between the single nucleotide polymorphism in CCR5 gene promoter and HIV infection
摘要
Abstract
Objective To explore the association between the single nucleotide polymorphism (SNPs) in CCR5 gene promoter and HIV infection. Methods All case-control studies about the association between the SNPs in CCR5 gene promoter and HIV infection in the Pubmed database were searched. Literatures were selected to extract the relevant data, which were used for Meta-analysis by Stata 10.0. Results Eight case-control studies with a total of 983 cases and 1 274 controls were included. 4 kinds of the SNPs sites in CCR5 gene promoter were analyzed, including 59029A/G, 59353T/C, 59356C/T, and 59402A/G loci. Fixed effect model was applied to analyze 59029A/G and 59353T/C because of the smaller heterogeneity. Meta-analysis showed that 59029G and 59353C allele mutations were not related to HIV infection (OR = 1.07, 95%CI0.90to 1.07; OR = 0.95, 95%C/0.81 to 1.11). Random effect model was applied to analyze 59356C/T and 59402A/G because of the larger heterogeneity. The results showed that the overall OR of 59356C/T and 59402A/G were 1.34 (95%CI 0.86 to 2.11) and 0.88 (95%CI 0.63 to 2.11). Conclusions The SNPs in CCR5 gene promoter was not likely related to HIV infection.关键词
HIV/趋化因子受体5/启动子/单核苷酸多态性/Meta分析Key words
HIV/ CCR5/ Promoter/ SNPs/ Meta-analysis引用本文复制引用
朱文昌,聂军,李建栋,王云芸,陈清,俞守义..趋化因子受体5基因启动子单核苷酸多态性与HIV易感性关系的Meta分析[J].实用医学杂志,2012,28(11):1785-1787,3.基金项目
十一五国家科技攻关重大项目(编号:2009ZX10001-0187) （编号:2009ZX10001-0187）
广州市科技攻关重点项目(编号:2006Z1-E0091) （编号:2006Z1-E0091）
