实用医学杂志2012，Vol.28Issue(11)：1788-1790,3.DOI:10.3969/j.issn.1006-5725.2012.11.014
CD4+CD25+FOXP3+调节性T细胞在结核病发生中的作用研究
Study on the role of CD4+ CD25+ FOXP3+ regulatory T cells in-tuberculosis
摘要
Abstract
Objective To determine the role of CD4+ CD25 + FOXP3 + regulatory T cells in tuberculosis. Methods The retrospective analysis is usedin our 60 cases of tuberculosis patients (obeservation group) and 60 cases of healthy (control group) check-up clinical data. Results Before treatment, CD4+ CD25 + FOXP34" regulatory T cells ratio of the observation group is significantly higher than the control group but significantly redued after treatment on them. The observation group CD4+ CD25 + FOXP34" regulatory T cells and CD4+ T cells proportion, CD8+ T cells, IFN-7 and IL-4 showed a significant negative correlation(P ＜ 0.05). Conclusion The role of CD4 + CD25+ FOXP3+ regulatory T cells in the pathogenesis of tuberculosis are very important, providing a new target for immunotherapy and tuberculosis vaccine design as well as clinical application.关键词
结核/CD4+CD25+FOXP3+调节性T细胞/免疫Key words
Tuberculosis/ CD4+ CD25+ FOXP3+ regulatory T cells/ Immunity引用本文复制引用
陈永浩,徐建辉,林庆裕,刘志辉,陈志成..CD4+CD25+FOXP3+调节性T细胞在结核病发生中的作用研究[J].实用医学杂志,2012,28(11):1788-1790,3.基金项目
广东省自然科学基金项目(编号:10151009509000007) （编号:10151009509000007）
