实用医学杂志2012，Vol.28Issue(16)：2684-2686,3.DOI:10.3969/j.issn.1006-5725.2012.16.014
XRCC3基因Thr241Met(rs861539)位点单核苷酸多态性与鼻咽癌的相关性
The association between single nucleotide polymorphisms of XRCC3 gene Thr241Met (rs861539) site and nasopharyngeal carcinoma susceptibility
摘要
Abstract
Objective The aim of this paper was to study the association between single nucleotide polymorphisms (SNP) of XRCC3 gene Thr241Met (rs861539) site and the susceptibility of nasopharyngeal carcinoma in Cantonese. Methods A total of 127 NPC patients and 117 age-matched and gender-matched healthy controls were enrolled in this study. C/T genotyping of the SNP locus rs861539 in XRCC3 gene was performed by PCR and DNA sequencing of the PCR products. Results The genotype frequency of heterozygote C/T was higher in healthy individuals (OR = 0.473,95% CI = 0.244-0.917 ,P ＜ 0.05). And the difference only existed in age ＜30 (OR = 0.071, 95% CI = 0.007-0.722, P ＜ 0.05) or male group (OR = 0.469, 95% CI = 0.232-0.947, P ＜ 0.05) when analyzing after stratification by age and gender. No association was found for the homozygote variant T/T( OR = 1e9, 95% CI = 0-∞, P ＞ 0.05) in two groups. Conclusion The SNP of XRCC3 gene Thr241Met (rs861539) site may be irrelevant to the genetic susceptibility of NPC in Cantonese.关键词
鼻咽肿瘤/单核苷酸多态性/XRCC3Key words
Nasopharyngeal neoplasms/ Single nucleotide polymorphisms/ XRCC3引用本文复制引用
张应蒙,叶尔佳,王宏梅,石玉生,陈龙华..XRCC3基因Thr241Met(rs861539)位点单核苷酸多态性与鼻咽癌的相关性[J].实用医学杂志,2012,28(16):2684-2686,3.基金项目
国家自然科学基金(编号:30800276) （编号:30800276）
广东省科技计划项目(编号:2010B031600245) （编号:2010B031600245）
