实用医学杂志2012，Vol.28Issue(16)：2699-2701,3.DOI:10.3969/j.issn.1006-5725.2012.16.020
小蔓长春花提取物对脑梗死大鼠抗氧化能力的作用
Effects of vinca minor linn extraction on the antioxidant capacity in rats with cerebral infarction
摘要
Abstract
Objective To study the effects of Vinca minor linn extraction (VMLE) on the hemorheology and antioxidant capacity in rats with experimental cerebral ischemia. Methods Rat models with middle cerebral artery occlusion (MCAO) were made by Zea-Longa traditional method. Then the scores of behavior were evaluated in MCAO rats by Bederson method. All the rat models were randomly divided into 4 groups: model group, nimodipine group, VMLE high and low dose groups (10 g/kg and of 5 g/kg of VMLE ) , and sham group. Rats in each group received corresponding drugs by gavage for 2 days. The hemorheology and antioxidant capacity of rats were detected 48 hours later. Results Blood viscosity, plasma viscosity, hematocrit,erythrocyte aggregation index, erythrocyte rigidity index, and level of MDA were significantly decreased and SOD and GSH-PX activity were enhanced in VMLE high and low dose groups (P ＜ 0;05 ) ; Nimodipine could enhance SOD and GSH-PX activity and decrease the level of MDA, but couldn't affect the blood viscosity, plasma viscosity, and hematocrit. Conclusion VMLE can significantly improve hemorheology and antioxidant capacity in rats with cerebral ischemia.关键词
脑梗死/小蔓长春花提取物/大鼠/MCAO模型/血流变Key words
Brain infarction/ Vinca minor linn extraction/ Rat/ MCAO model/ Hemorheology引用本文复制引用
靳萍奎,姜相明,顾平,王彦永,崔冬生,耿媛,张忠霞..小蔓长春花提取物对脑梗死大鼠抗氧化能力的作用[J].实用医学杂志,2012,28(16):2699-2701,3.基金项目
河北省国际科技合作计划项目(编号:07396104D) （编号:07396104D）
