实用医学杂志2012，Vol.28Issue(17)：2823-2825,3.DOI:10.3969/j.issn.1006-5725.2012.17.001
苦参碱对HepG2细胞DLK1基因表达及细胞生长的影响
Effects of matrine on the growth and expression of DLK1 in HepG2 cells
摘要
Abstract
Objective To investingate the effects of matrine on the growth and expression of DLK1 in human hepato cellular carcinoma cell line HepG2. Methods HepG2 cells were treated with different concentrations of matrine, RT-PCR was used for the detection of DLK1 gene expression level; MTT, transwell and flow cytometry were used for the detections of HepG2 cell growth, invasiveness and apoptosis. Results After treated with matrine, HepG2 cells DLK1 gene mRNA expression, cell growth rate and invasive ability decreased. Conclusion Matrine can effectively inhibit DLK1 gene expression, cell growth, proliferation and invasion of HepG2.关键词
苦参碱/DLK1基因/HepG2细胞Key words
Matrine/ DLK1/ HepG2引用本文复制引用
罗耀玲,黄铀新,刘瑶..苦参碱对HepG2细胞DLK1基因表达及细胞生长的影响[J].实用医学杂志,2012,28(17):2823-2825,3.基金项目
国家自然科学基金资助项目(编号:81000908) （编号:81000908）
