实用医学杂志2012，Vol.28Issue(17)：2839-2841,3.DOI:10.3969/j.issn.1006-5725.2012.17.006
星状神经节阻滞对内毒素血症小鼠炎性细胞因子水平及死亡率的影响
Effects of SGB on serum cytokines and mortality of mice with endotoxemia
摘要
Abstract
Objective To determine the feasibility of stellate ganglian block (SGB) therapy for the treatment of mice with endotoxemia. Methods Kun ming mice injected with 2 mg/kg Lipopolysaccharide (LPS) intraperitonealy were divided into control group (untreated by SGB) and SGB group (treated daily by SGB). The roles of SGB were evaluated by comparing mortality and serum TNF-α, IL-1β, IL-6 levels in each group. Results Compared with control group, Mortality in SGB group decreased significantly at 2, 4, 7, 10, 15, 20 d after injecting LPS intraperitonealy. Serum TNF-a, IL-1β, IL-6 levels decresed obviously in SGB group than that in control group. Conclusions These results indicate that SGB is a effective central therapeutic approach for treatment of endotoxemia. SGB can regulate systemic lnfammatory responses, which maybe mechanisms for effectiveness of SGB on mortality in mice with endotoxemia.关键词
内毒素血症/星状神经节阻滞/死亡率/细胞因子Key words
stellate ganglian block/ endotoxemia/ mortality/ cytokine引用本文复制引用
李建玉,宋骤,杨雪,吴群林,陆建华..星状神经节阻滞对内毒素血症小鼠炎性细胞因子水平及死亡率的影响[J].实用医学杂志,2012,28(17):2839-2841,3.基金项目
国家973创伤项目01课题(编号:G1999054201) （编号:G1999054201）
