实用医学杂志2012，Vol.28Issue(18)：3028-3030,3.DOI:10.3969/j.issn.1006-5725.2012.18.018
DC-CIK联合化疗对晚期肾癌患者外周血中微转移表达的影响
Effects of dendritic cells and cytokine induced killer cells combined with chemotherapy on the micrometastases in peripheral blood in patients with late stage renal cell carcinoma
摘要
Abstract
Objective To investigate the change of the expression of G250 mRNA in peripheral blood of patients with metastatic renal cell carcinoma (mRCC) after dendritic cells and cytokine induced killer cells (DC-CIK) combined with chemotherapy treatment, and to discuss its correlation with biochemotherapy effects. Methods The expression of G250 mRNA in peripheral blood of 31 patients with mRCC before and after 2 weeks of DC-CIK combined with chemotherapy treatment was detected by qRT-PCR. Results After the treatment, the expression of G250 mRNA was decreased in 18 (58.1%) cases, stable in 5 (16.1%) cases, and was increased in 8 (25.8%). cases (P < 0.01); 11>(35.5%) cases were partial remission (PR), 9 (29.0%) cases were stable (SD), 11 (35.5% ) cases were progress (PD). The expression of G250 mRNA was correlated with the efficacy of biochemotherapy (r = 0.498). Conclusions Detection of the expression of G250 mRNA in peripheral blood may be used to evaluate the efficacy of biochemotherapy.关键词
肾肿瘤/树突状细胞/细胞因子诱导的杀伤细胞/化学治疗Key words
Kidney neoplasms/ Dendritic cell/ Cytokine induced killer/ Chemotherapy引用本文复制引用
韩正祥,张兰胜,王晓友,高向阳,杜秀平,郑骏年..DC-CIK联合化疗对晚期肾癌患者外周血中微转移表达的影响[J].实用医学杂志,2012,28(18):3028-3030,3.基金项目
徐州市科技局基金资助项目(编号:XM09B052) （编号:XM09B052）
