实用医学杂志2012，Vol.28Issue(19)：3219-3222,4.DOI:10.3969/j.issn.1006-5725.2012.19.023
维持性血液透析患者代谢性酸中毒对钙磷代谢的影响
Metabolic acidosis and its effect on calcium and phosphorus metabolism in maintenance hemodialysis patients
黎晓磊 1邵咏红 1孔耀中1
作者信息
- 1. 528000 广东省佛山市,中山大学附属佛山医院/佛山市第一人民医院肾内科
- 折叠
摘要
Abstract
Objective To evaluate the effect of metabolic acidosis on calcium and phosphorus metabolism in maintenance hemodialysis(MHD) patients. Methods 120 MHD patients were enrolled in the present study. Predialysis laboratory detections including HC03", BUN creatinine, calcium, phosphorus, alkaline phosphatase (ALP) and intact parathyroid hormone (iPTH) were performed. Calcium-phosphate product and Kt/V were also determined. The patients were randomized into 3 groups: group A(HCO3- ＜ 20 mmol/L), group B (20 mmol/L≤HCO-3＜ 24 mmol/L), group C (HCO3-≥ 24 mmol/L). Results The concentrations of phosphorus, ALP and iPTH were decreased in groups B and C in comparation to that in group A (P ＜ 0.05). Compared with group A and B, the phosphorus and calcium-phosphate product level in group C were decreased (P ＜ 0.05). The serum HCO3" level correlated negatively with the serum phosphorus, iPTH, ALP and calcium-phosphate product (P ＜ 0.05). Conclusions Correction of metabolic acidosis (bicarbonate level -S 20 mmol/L) may prevent the deleterious long-term consequences such as CKD-MBD, but further investigation of the long-term effect still needs to be done.
关键词
肾透析/代谢性酸中毒/钙磷代谢Key words
Renal dialysis/ Metabolic acidosis/ Calcium and phosphorus metabolism引用本文复制引用
黎晓磊,邵咏红,孔耀中..维持性血液透析患者代谢性酸中毒对钙磷代谢的影响[J].实用医学杂志,2012,28(19):3219-3222,4.
