实用医学杂志2012，Vol.28Issue(20)：3383-3385,3.DOI:10.3969/j.issn.1006-5725.2012.20.024
小剂量氨茶碱对COPD稳定期患者血浆及诱导痰中IL-13水平的影响
Effects of low-dose aminophylline on the levels of IL-13 in plasma and induced sputum in patients with stable chronic obstructive pulmonary disease
符丹丹 1欧阳瑶1
作者信息
- 1. 563000 遵义医学院附属医院呼吸一科
- 折叠
摘要
Abstract
Objective To investigate the effects of low-dose aminophylline on chronic airway inflammation in patients with stable chronic obstructive pulmonary disease (COPD). Methods 40 patients with stable COPD were randomly divided into 2 groups: aminophylline group (n = 20) and control group (n = 20). All patients in both groups received routine home oxygen therapy and pulmonary functional exercise, and the patients in aminophylline group also received lOOmg of aminophylline orally, three times a day. The levels of IL-13 in blood and induced sputum (IS) samples harvested from COPD patients and 10 cases of healthy controls before and 30 days after the treatment were determined by ELISA assay. Results The levels of IL-13 in plasma and IS were higher in both aminophylline group and control group than those in healthy controls, respectively (P＜ 0.01). Meanwhile, the levels of IL-13 in both plasma and IS were lower in aminophylline group than those in control group (P ＜ 0.01). Conclusions Aminophylline could significantly exhibit the anti-inflammatory effect by decreasing the level of IL-13 in both plasma and IS in patients with stable COPD.
关键词
肺疾病慢性阻塞性/肺功能/白介素-13/诱导痰Key words
Chronic obstruction pulmonary disease/ Pulmonary function/ Interleukin-13 (IL-13)/ Induced sputum引用本文复制引用
符丹丹,欧阳瑶..小剂量氨茶碱对COPD稳定期患者血浆及诱导痰中IL-13水平的影响[J].实用医学杂志,2012,28(20):3383-3385,3.
