摘要
Abstract
Objective: To evaluate the clinical effects on the patients with diminished ovarian reserve treated hy different controlled ovarian hyperstimulation (COH) schemes.
Methods: A comparatively retrospective analysis was performed in 114 patients (age ^35) who underwent in vitro fertilization and embryo transfer (IVF-ET). They were divided into 5 groups based on different protocols of COH: modified long protocol group (group A, 96 cycles) , Cetrotide protocol group (group B, 76 cycles), minimal ovarian stimulation group (group C, 43 cycles), modified ultra-long protocol group (group D, 77 cycles) , and long protocol group with short-acting using 0. 05 mg/day Triporelin (group E, 63 cycles). The clinical data and the outcomes of IVF/ICSI-ET were compared among the 5 groups.
Results: There were no significant differences among the 5 groups in female patient age, duration of infertility, base FSH levels, good quality embryo rate, M ]] oocyte rate, fertility rate (P>0. 05). No significant differences were found in duration of gonadotropin (Gn) used, Gn ampouls used, number of oocyte retrieval, number of good quality embryo, cycle cancellation rate and clinical pregnancy rate among group A, group B, group D and group E, but duration of Gn used, Gn ampouls used, number of oocyte
retrieval and clinical pregnancy rate in group A. B, D, E were significantly higher than those in group C, and the cycle cancellation rate was lower than that in group C (P<Z0. 05). The fertility rate was not significant different among group B, group C, group D and group E, hut which was significantly higher than that in group A (.P<Si. 05). The abortion rate was not significant different among group A, group C, group D and group E, hut which was significantly lower than that in group B (P<Z0. 05).
Conclusions: Long protocol of down regulation with 0. 05 mg/day Triporelin or modified ultra-long protocol can he good choice for patients with poor ovarian reserve in controlled ovarian hyperstimulation.
关键词
微刺激方案/卵巢储备功能下降/控制性超促排卵Key words
Mini-stimulation protocol/ Diminished ovarian reserves/ Controlled ovarian
hyperstimulation.
