生殖医学杂志2012，Vol.21Issue(6)：588-592,5.DOI:10.3969/j.issn.1004-3845.2012.06.022
类固醇激素合成急性调节蛋白在大鼠多囊卵巢中的表达
Expression of steroidogenic acute regulatory protein in rats with polycystic ovarian syndrome
摘要
Abstract
Objective: To explore the expression of steroidogenic acute regulatory protein (StAR) in the polycystic ovary of the rat with polycystic ovarian syndrome (PCOS) induced hy dehydroepiandrosterone (DHEA) , and the relationship between hormonal secretion and estral changes. Methods: The model of rat with PCOS was established by DHEA injection. The serum levels of progesterone (P) and estrogen (E2) were measured by immunoradioassay. The expression of StAR and steroidogenic factor-l(SF-l) were detected by immunohistochemistry and Western blotting. Results: The polycystic ovary phynomena was present in the rat model. The serum levels of E2 in PCOS group was significantly higher than those in normal control (NC) group (,P<Si. 01). There was no significant difference of serum P levels between PCOS and NC group (P>0. 05). The expressions of StAR and steroidogenic factor-1 (SF-1) in PCOS group were significantly higher than those in the NC group (P <0. 05). Conclusions: The higher expression of StAR was regulated by SF-1 in the model of rat with PCOS induced by DHEA. The increase of serum E2 level was independent with StAR expression.关键词
多囊卵巢综合征/脱氢表雄酮/类固醇激素合成急性调节蛋白Key words
Polycystic ovarian syndrome/ Dehydroepiandrosterone/ Steroidogenic acute regulatory protein引用本文复制引用
林伟,宋张娟,董磊,赵瑞,汪洋..类固醇激素合成急性调节蛋白在大鼠多囊卵巢中的表达[J].生殖医学杂志,2012,21(6):588-592,5.基金项目
浙江省教育厅科研基金资助项目(Y200803848) （Y200803848）
温州市科技局科研基金资助项目(Y20080131) （Y20080131）
温州医学院学生科研资助项目(WYX201001056) （WYX201001056）
