西北国防医学杂志2012，Vol.33Issue(6)：601-604,4.
比格犬严重多发伤动物模型的研制
Establishment of an animal model of severe multiple trauma in Beagle dogs
摘要
Abstract
Objective;To establish an animal model of severe multiple trauma, and to explore its stability and rescuing effect. Methods; Thirty - one healthy Beagle dogs were randomly divided into two groups. One was the group of severe multiple trauma, haemorrhegic shock model and another was the group of severe multiple trauma, thoraco - abdominal combined trauma, upper respiratory tract obstruction asphyxia model. Sensibility and specificity between the two groups were compared. Results; Shaping rates of two groups could meet with all the requirement of different experiments. All the animals survived when autologous blood transfusion plus fluid resuscitation were taken by our patented equipment. Half of the animals survived when single fluid resuscitation was applied. The general mortality of asphyxia was 23. 1 % . All the animals with asphyxia for less than 6 min survived and the survival rate of animals with asphyxia for more than 9 min was 60%. Conclusion; Severe multiple trauma, upper respiratory tract obstruction asphyxia and haemorrhegic shock model is fit for on - site clinical reality with a higher shaping rate and stability. It covers several aspects of severe dangerous trauma. Half lethality is approximated to the expected probability. It provides evidence for the research of on - site rescuing skill, rescuing equipment and for the evaluation of rescuing efficacy.关键词
创伤急救/上呼吸道窒息/出血休克/动物模型/比格犬Key words
On - site rescuing/ Upper respiratory tract asphyxia/ Hemorrhagic shock/ Animal model/Beagle dog分类
医药卫生引用本文复制引用
李庆新,郑军,张世范,孟辉,杨俊峰,高炜,刘传兰..比格犬严重多发伤动物模型的研制[J].西北国防医学杂志,2012,33(6):601-604,4.基金项目
甘肃卫生行业科研计划项目(GSWST09-19),甘肃省科技支撑计划资助项目(1104FKCA106、1104FKCA069) （GSWST09-19）
