现代妇产科进展2012，Vol.21Issue(9)：669-672,4.
子痫前期孕妇血清和胎盘组织中干扰素-γ诱导蛋白10的表达及意义
Expression and significance of IFN-γ inducible protein 10 in serum and placenta with preeclampsia pregnancy
摘要
Abstract
Objective:To detect interferon-gamma inducible protein 10(IP-10) in the placenta and serum of gravidas with preeclampsia in order to evaluate the relationship of IP-10 with preeclampsia. Methods: We collected placenta and serum from normal gravidas, gravidas with mild preeclampsia and gravidas with severe preeclampsia. The expression of IP-10 in the placenta and serum was detected by ELISA, real-time PCR and Western blot. Results: As the results of ELISA, the IP-10 expression levels in serum of patients with severe or mild preeclampsia were significantly higher than those in normal pregnancy group ( P<0. 05 ). And as the results of real-time PCR and Western blot, the expression levels of IP-10 in the placenta with severe or mild preeclampsia were all significantly higher than those in normal pregnancy group (P<0. 05). Conclusion: The elevated IP-10 expression in the placenta and serum may play an important role in preeclampsia.关键词
干扰素-γ诱导蛋白10/子痫前期/血清/胎盘/干扰素诱导剂/干扰素-γKey words
IFN-7 inducible protein 10/Pre-eclampsia/Serum/Placenta/Interferon in-ducers/Interferon-gamma分类
医药卫生引用本文复制引用
宋建华,张学光,孙华,张光波,胡晓红,薛爱丽..子痫前期孕妇血清和胎盘组织中干扰素-γ诱导蛋白10的表达及意义[J].现代妇产科进展,2012,21(9):669-672,4.基金项目
南通市社会发展计划(No:S2008032) （No:S2008032）
江苏省卫生厅"科教兴卫工程"苏州大学附属第一医院临床免疫实验室开放课题(No:KF200973) （No:KF200973）
