现代妇产科进展2012，Vol.21Issue(12)：917-920,4.
GDM孕妇血清晚期糖基化终产物水平与其胎儿出生缺陷的关系及临床意义
Relationship between GDM maternal advanced glycation end products level and fetal birth defects and it's clinical significance
摘要
Abstract
Objective:To detect serum advanced glycation end products(AGE) level in gestation diabetic mother( GDM) gestational period and fetal cord blood, and observe the RAGE protein expression in placenta. To explore the clinical significance of relationship be-tween fetal birth defects and AGE levels in prenatal screening. Methods: Gestational diabetes pregnant woman confirmed fetalmalformation or fetal death by prenatal diagnosis were enrolled as the study group, total of 42 cases; Randomly selected the GDM fetal normalities pregnant women,as the GDM group,30 cases;another 30 cases of the normal pregnant women wre select-ed randomly as healthy control group. Maternal peripheral blood and the specimens of fetal cord blood specimens were collected to detect AGE by enzymatic assay. The line RAGE immunohis-tochemistry. Results;The case group, the GDM group and healthy control group fetal cord blood serum AGE levels were(223. 9±54. 6) , (160. 7±37. 2) , (108. 3±15. 8) μg/L, Comparison of the difference were statistically significant (P<0. 05). The case group, the GDM group and healthy control group maternal serum AGE levels were(169. 1±14.3) ,(105.4±17.2) ,(80.6 11.4) μg/L, comparison of the difference were statistically significant (P<0. 05). The case group,the GDM group and healthy control group the RAGE protein positive expression rate in placental tissue were 87. 5%、53. 1%、29. 6% ,the difference were statistically significant (P< 0.05). Conclusions: GDM maternal AGE hyperlipidemia is the risk factors for fetus birth de-fects , Pregnant women serum AGE levels can be used as GDM birth defects of prenatal screen-ing index.关键词
晚期糖基化终产物/妊娠期糖尿病/胎儿/先天畸形/产前诊断/胎盘/血清Key words
Advanced glycosylation end products/Gestation diabetes mellitus/Fetus/Congenital abnormalities/Prenatal diagnosis/Placenta/Serum分类
医药卫生引用本文复制引用
汤栩文,林斯,谢晓斌..GDM孕妇血清晚期糖基化终产物水平与其胎儿出生缺陷的关系及临床意义[J].现代妇产科进展,2012,21(12):917-920,4.基金项目
2011年度广州市卫生局医药卫生科技项目,一般引导项目(No:201102A213037) （No:201102A213037）
