现代妇产科进展2012，Vol.21Issue(12)：925-928,4.
不同年龄和流产次数的复发性流产患者绒毛染色体核型分析
Effect of maternal age and miscarriage number on karyotype analysis of chorionic villus in recurrent spontaneous abortion
摘要
Abstract
Objective;To investigate the chromosomal aberration in the abortus of re-current spontaneous abortion. Methods: From Jan. 2008 to Dec. 2011, chromosomal analysis was performed on products of conception of 235 pregnancies with early pregnancy loss. The frequen-cy and type of chromosomal anomalies in recurrent spontaneous abortion and sporadic abortion were compared. The frequency of embryonic chromosomal anomalies in relation to the number of miscarriage were analyesd. Results; Chromosomal abnormality rate in recurrent spontaneous a-bortion group was lower compared with sporadic abortion group (47. 2% vs 70. 9% ,P<0. 05). The frequency of trisomy in recurrent spontaneous abortion group was higher than that of spo-radic abortion group (66. 1% vs 44. 8% ,P<0. 05 ) . The frequency of abnormal embryonic kar-yotypes significantly decreased with the number of spontaneous abortion ( X2 = 15. 266, P= 0.004). The abnormal embryonic karyotype in women aged ≥35 years old was higher than that in women aged<35 years old (P<0.05). Conclusion: Chromosomal anomaly is a major reason of recurrent spontaneous abortion. The frequency of abnormal embryonic karyotype significantly decreases with the number of abortion. Advancing maternal age is a risk factor for abnormal em-bryonic karyotype.关键词
流产,自然/复发性自然流产/核型分析/绒毛/染色体Key words
Abortion,spontaneous/Recurrent spontaneous abortion/Karyotyping/Cho-rionic villus/Chromosomes分类
医药卫生引用本文复制引用
刘玉昆,刘梅兰,杜涛,陈颖,陈慧,张建平..不同年龄和流产次数的复发性流产患者绒毛染色体核型分析[J].现代妇产科进展,2012,21(12):925-928,4.基金项目
广东省自然基金博士启动基金(No:06021369) （No:06021369）
国家自然基金(No:81170625) （No:81170625）
