烟草科技Issue(12)：44-48,5.
LC-MS/MS同时测定卷烟主流烟气中4种芳香胺
Simultaneous Determination of Four Aromatic Amines in Mainstream Cigarette Smoke with Liquid Chromatography Tandem Mass Spectrometry
摘要
Abstract
For simultaneous determination of four aromatic amines, including 1-naphthylamine, 2-naphthylamine, 3-aminobiphenyl and 4-aminobiphenyl, in mainstream cigarette smoke, a liquid chromatography tandem mass spectrometric (LC-MS/MS) method was developed. The contents of the four aromatic amines in mainstream smoke of domestic and foreign cigarettes with different tar deliveries were determined with the developed method, and the resultant were compared with that determined with GC-MS method. The results showed that: 1) The limits of detection of LC-MS/ MS method ranged from 0.016 to 0.038 ng/mL with the recoveries from 70.5% to 116.5%, and the intra-day and inter-day precisions were less than 6% and 9%, respectively. 2) The resultant of LC-MS/MS method well correlated with that of GC-MS method. The developed method was fast, simple, sensitive and suitable for the simultaneous determination of the said aromatic amines in mainstream cigarette smoke.关键词
LC-MS/MS/主流烟气/芳香胺Key words
LC-MS/MS/Mainstream cigarette smoke/Aromatic amine分类
轻工纺织引用本文复制引用
余晶晶,王昇,谢复炜,陈玉松,赵阁,张晓兵..LC-MS/MS同时测定卷烟主流烟气中4种芳香胺[J].烟草科技,2012,(12):44-48,5.基金项目
国家自然科学基金项目"卷烟烟气中主要杂环胺类化合物的体内代谢研究"(21005087) （21005087）
中国烟草总公司郑州烟草研究院院长科技发展基金项目"高效液相色谱-串联质谱法检测卷烟主流烟气中的芳香胺"(312010CA0220). （312010CA0220）
