诊断学理论与实践2012，Vol.11Issue(6)：580-584,5.DOI:10.3969/j.issn.1671-2870.2012.06.011
非小细胞肺癌组织表皮生长因子受体磷酸化水平与患者临床疗效的关系
Phosphorylation level of epidermal growth factor receptor and its relationship with clinical outcomes in non-small cell lung cancer
摘要
Abstract
Objective: To study the level of expression and phosphorylation of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC), and analyze its relationship with clinical features and outcomes of NSCLC. Methods Seventy-five patients of NSCLC were enrolled. Specimens were collected from operation. Immunohistochemistry was used to detect the levels of EGFR and phosphorylated EGFR (p-EGFR) in tumor tissue. The relationships between level of EGFR and p-EGFR and clinicopathological features and therapeutic outcome were analyzed. Results EGFR and p-EGFR were higher in NSCLC tissue than in para-cancerous tissue, the positive rates were 78.67% and 56.00% , respectively. EGFR expression was correlated with cancer cell differentiation, and p-EGFR was correlated with cancer cell differentiation, lymph node metastasis, and clinical stage. Those with poor differentiation, metastasis and late stage had higher level of p-EGFR. The level of p-EGFR was correlated clinically with therapeutic efficacy. Conclusions Phosphorylated EGFR might be useful for the judgment of NSCLC progression and clinical outcome. The level of p-EGFR is helpful for evaluating the outcome and prognosis of NSCLC.关键词
肺癌/表皮生长因子受体/磷酸化/信号转导/临床疗效Key words
Lung cancer/ Epidermal growth factor receptor/ Phosphorylation/ Signal transduction/ Clinical outcome分类
医药卫生引用本文复制引用
陈洁,楼朝阳,徐天骄,郭东桃,佘晶晶,王刚..非小细胞肺癌组织表皮生长因子受体磷酸化水平与患者临床疗效的关系[J].诊断学理论与实践,2012,11(6):580-584,5.基金项目
国家自然科学基金(81170499) （81170499）
