中国当代儿科杂志2012，Vol.14Issue(10)：759-762,4.
人神经前体细胞移植治疗重度脑瘫患儿疗效观察
Treatment of cerebral palsy with transplantation of human neural progenitor cells
刘卫鹏 1屈素清 1栾佐 1龚小军 1汪兆艳1
作者信息
摘要
Abstract
Objective To study the clinical efficacy of transplantation of human neural progenitor cells (hNPCs) in the treatment of severe cerebral palsy (CP) in children. Methods Forty-five children with CP were voluntarily accepted transplantation of hNPCs. The cells obtained from the forebrain of 10 to 12-week-fetus were cultured and amplified into hNPCs. Then the hNPCs were injected into the cerebral ventricle of the patients with the supersonic guidance. Results Dyssomnia, irritability and muscular tension were improved in one patient 3 days after transplantation. The clinical improvements were observed in the majority of the patients 1 month after transplantation. The therapeutic effects slowed down 3 to 6 months after transplantation. One year after transplantation the gross and fine motor skills and the congnition ability in the transplantation group were considerably surpassed to those in the control group. No delayed severe complications were observed after transplantation. No tumorigenesis was noted 5 years after transplantation. Conclusions The transplantation of hNPCs as a novel therapy is effective and safe for severe CP. Many investigations are needed to evaluate the effect of the therapy.关键词
神经前体细胞/移植/脑性瘫痪/儿童Key words
Human neural progenitor cell/Transplantation/Cerebral palsy/Child分类
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刘卫鹏,屈素清,栾佐,龚小军,汪兆艳..人神经前体细胞移植治疗重度脑瘫患儿疗效观察[J].中国当代儿科杂志,2012,14(10):759-762,4.
