中国当代儿科杂志2012，Vol.14Issue(10)：767-770,4.
血清25-羟维生素D在佝偻病诊断中的应用价值
Role of serum 25-hydroxyvitamin D in the diagnosis of vitamin D deficiency rickets
王晓燕 1金春华 1吴建新 2刘卓 2李梅 1李娜1
作者信息
- 1. 首都儿科研究所附属儿童医院保健科,北京100020
- 2. 首都儿科研究所生化研究室,北京 100020
- 折叠
摘要
Abstract
Objective To study the role of serum 25-hydroxyvitamin D in the early diagnosis of vitamin D deficiency rickets. Methods Concentrations of serum 25(OH) D, calcium, phosphorus and alkaline phosphatase were measured in normal control ( n = 73 ) , suspected rickets ( n = 45 ) and confirmed rickets groups ( n = 65 ). Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum 25 ( OH) D for rickets. Results Serum 25(OH)D levels in the suspected and confirmed rickets groups were 83 ±30 and 72 ±31 nmol/L respectively, which was lower than in the normal control group (112 ± 37 nmol/L) ( P < 0. 01) . There was no significant difference between the suspected and confirmed rickets groups ( P > 0. 05 ). Vitamin D deficiency rates in the suspected and confirmed rickets groups were higher than in the control group ( P < 0. 01) . The ROC curve area of serum 25 ( OH) D for the diagnosis of rickets was 0. 760 (95% CI 0. 692 - 0. 820, P < 0. 01 ) , and the optimal operating point was 90. 70 nmol/L ( sensitivity 68.49% , specificity 72. 73%). There was no significant difference in levels of calcium, phosphorus and alkaline phosphatase between the three groups ( P > 0. 05 ) . Conclusions Serum 25 ( OH) D levels in infants with suspected and confirmed rickets are significantly reduced and this may reflect vitamin D deficiency . Therefore, it may be useful to check serum 25(OH)D levels in screening for rickets.关键词
25-羟维生素D/维生素D缺乏性佝偻病/婴儿Key words
25-Hydroxyvitamin D/Vitamin D deficiency rickets/Infant分类
医药卫生引用本文复制引用
王晓燕,金春华,吴建新,刘卓,李梅,李娜..血清25-羟维生素D在佝偻病诊断中的应用价值[J].中国当代儿科杂志,2012,14(10):767-770,4.
