中国当代儿科杂志2012，Vol.14Issue(10)：800-802,封3,4.
Gata4转录后蛋白共价修饰
Post-transcriptional protein modification of Gata4
摘要
Abstract
Gata4 is an important transcription factor in heart development. Gata4 post-transcriptional protein modification regulates transcriptional activity and DNA binding, which in turn affects expression of downstream genes and transcription factors, differentiation of embryonic stem cells and cardiogenesis. This article summarizes the effect of post-transcriptional protein modification on transcriptional activity of Gata4 and the relationship between this effect and congenital heart disease. It was shown that acetylation, phosphorylation and SUMOylation upregulate transcriptiona) activity, DNA binding, downstream gene expression and embryonic stem cell differentiation. On the other hand, methylation and deacetylation downregulate Gata4 transcriptional activity. Post-transcriptional protein modification of Gata4 is very important in clinical research on congenital and other heart diseases.关键词
蛋白共价修饰/心脏发生/先天性心脏病Key words
Protein modification/Cardiogenesis/Congenital heart disease分类
医药卫生引用本文复制引用
俞立玮..Gata4转录后蛋白共价修饰[J].中国当代儿科杂志,2012,14(10):800-802,封3,4.基金项目
国家自然科学基金面上项目 （）
批准号:81170147 （）
