中国当代儿科杂志2012，Vol.14Issue(11)：838-841,4.
机械通气早产儿脑室周围-脑室内出血临床高危因素分析
Risk factors for periventricular-intraventricular hemorrhage in premature infants treated with mechanical ventilation
徐发林 1段佳佳 1张彦华 1张晓丽 1郭佳佳1
作者信息
- 1. 郑州大学第三附属医院新生儿科,河南 郑州 450052
- 折叠
摘要
Abstract
Objective To study risk factors for periventricular-intraventricular hemorrhage ( PVH-IVH) in premature infants treated with mechanical ventilation. Methods A total of 205 premature infants who were admitted to the neonatal intensive care unit ( NICU) and treated with mechanical ventilation between January 2009 and December 2011 were enrolled. They were classified into PVH-IVH and non-PVH-IVH groups according to the results of head ultrasonography performed at 3 to 7 days after birth. Single factor and multivariate logistic regression analysis were used to identify risk factors for PVH-IVH. Results Single factor analysis indicated 9 factors associated with the development of PVH-IVH, including a gestational age of < 32 weeks, a birth weight of < 1500 g, intrauterine distress, severe asphyxia, vaginal delivery, maternal perinatal infection, premature rupture of membranes (PROM) at IS 8 hours, mechanical ventilation duration of ≥7 days and ventilator-associated pneumonia ( VAP) (P < 0. 05 ). Multivariate logistic regression analysis showed that a birth weight of < 1500 g (OR =2. 665 ) , intrauterine distress ( OR = 2. 177 ) , severe asphyxia ( OR = 5.653), maternal perinatal infection ( OR = A. 365 ) and VAP (OR =2.299) were independent risk factors for the development of PVH-IVH (P <0. 05). Conclusions Very low birth weight, intrauterine distress, severe asphyxia, maternal perinatal infection and VAP are closely associated with an increased risk of PVH-IVH in premature infants treated with mechanical ventilation. These clinical risk factors should be given more attention in the prevention of PVH-IVH.关键词
机械通气/脑室周围-脑室内出血/高危因素/早产儿Key words
Mechanical ventilation/Periventricular-intraventricular hemorrhage/Risk factor/Premature infant分类
医药卫生引用本文复制引用
徐发林,段佳佳,张彦华,张晓丽,郭佳佳..机械通气早产儿脑室周围-脑室内出血临床高危因素分析[J].中国当代儿科杂志,2012,14(11):838-841,4.
