中国动脉硬化杂志2012，Vol.20Issue(10)：918-922,5.
脂蛋白脂肪酶-447C/G基因多态性与老年脑梗死的关系
The Relationship Between Lipoprotein Lipase-447C/G Genepolymorphism and Cerebral Infarction in the Elderly
胡晓雁 1肖志杰 2刘晗睿 1常波 1秦蔚1
作者信息
- 1. 山西长治医学院附属和济医院神经内科,山西省长治市046011
- 2. 中南大学湘雅二医院神经内科,湖南省长沙市410011
- 折叠
摘要
Abstract
Aim To explore the relationship between the lipoprotein lipase (LPL) -447C/G gene polymor-
phism and cerebral infarction in the elderly.Methods This was a case-control study, which enrolled 206 cases with
cerebral infarction in the elderly and 203 elderly incerebrovascular disease controls. The genotype and allele frequencies of lipoprotein lipase -447 C/G gene polymorphism were assayed by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). The cerebral infarction patients were strictly diagnosed according to revise conference in the national fourth session of cerebrovascular disease. The basic document object of study was collection through questionnaire interview. Results The LPL - 447C/G genotype and allele distribution in the cerebral infarction group was CC
83.98%, CG + GG 16.02% and C 91.75%, G 8.25% respectively. The distribution in control group was CC 81.77%, CG + GG 18.23% and C 90.89%, G 9.11% respectively. There was no significant difference in LPL - 447C/G allele and genotype distribution between the cerebral infarction group and the control group ( P > 0. 05). There was no significant difference detected in blood pressure level and blood lipids level between various genotypes (P > 0. 05). Cerebral infarction multi-factor regression equation indicated primary hazard factors included smoking history, diabetes history and family history. Conclusions (1) LPL -447C/G gene polymorphism is not significantly associated with cerebral infarction in elderly. (2) LPL -447C/G gene polymorphism is not significantly associated with blood lipids level, blood pressure level in elderly.
关键词
脂蛋白脂肪酶/-447C/G/基因多态性/脑梗死/老年Key words
Lipoprotein Lipase/ -447 C/G/ Gene Polymorphism/ Cerebral Infarction/ Elderly分类
医药卫生引用本文复制引用
胡晓雁,肖志杰,刘晗睿,常波,秦蔚..脂蛋白脂肪酶-447C/G基因多态性与老年脑梗死的关系[J].中国动脉硬化杂志,2012,20(10):918-922,5.
