中国动脉硬化杂志2012，Vol.20Issue(10)：934-938,5.
钙离子拮抗剂和血管紧张素Ⅱ受体阻断剂对高血压患者动脉僵硬度影响的Meta分析
Meta Analysis of the Changes of Arterial Stiffness of Hypertension Patients with CCB or ARB
摘要
Abstract
Aim To evaluate the differences of the changes of arterial stiffness of hypertension patients with the treatment of calcium channel blocker ( CCB) or angiotensin Ⅱ receptor blocker ( ARB) . Methods Based on the principles of evidence-based medicine, corresponding inclusion and exclusion criteria, along with search strategies were developed. We searched the Ovid EMB Reviews, Pubmed, EMBASE, Chinese Biomedical Literature Database, Chinese Scientific Journal Full-text Database, and Chinese Journal Full-text Database up to January 2012 to identify randomized controlled trials ( RCT) comparing the effects of CCB with that of ARB on arterial stiffness of hypertension patients. Two reviewers independently evaluated the quality of the included studies, extracted data with a unified form, and analyzed the data by Cochrane Collaboration' s RevMan 5. 0 software. We compared the effects of CCB with ARB on pulse wave velocity (PWV) , SBP, DBP and PP of hypertension patients. Results Six RCT involving 411 paitents were included. The results of Meta analysis suggested that ARB was better than CCB in reducing arterial stiffness ( MD = 183. 33, 95% CI was 79. 32 ~ 287. 33) , but worse than CCB in lowering SBP ( MD = - 2. 66, 95% CI was - 3. 35～‐1. 96) or DBP (MD = - 5. 43 , 95% CI was -8.8～‐2. 07). Conclusion In the treatment of anti-hypertension, CCB is stronger than ARB. But the effect of ARB is better than that of CCB on reducing arterial stiffness. And it' s not related to their antihypertensive function. However, due to the quality of the included studies, the effects of CCB and ARB on arterial stiffness need to be confirmed by large multicenter randomized controlled trials.关键词
钙离子阻断剂/血管紧张素Ⅱ受体阻断剂/高血压/Meta分析Key words
Calcium Channel Blocker/ Angiotensin Ⅱ Receptor Blocker/ Hypertension/ Meta Analysis分类
医药卫生引用本文复制引用
张艺军,裴静娴,吴平生..钙离子拮抗剂和血管紧张素Ⅱ受体阻断剂对高血压患者动脉僵硬度影响的Meta分析[J].中国动脉硬化杂志,2012,20(10):934-938,5.基金项目
国家自然科学基金青年基金项目(30900659) （30900659）
