中国动脉硬化杂志2012，Vol.20Issue(11)：1003-1006,4.
冠心病患者动脉弹性与血清高敏C反应蛋白和基质金属蛋白酶9的相关性
Association of Arterial Elasticity with Serum High Sensitivity C-reactive Protein and Matrix Metallooroteinase-9 in Patients with Coronary Heart Disease
摘要
Abstract
Aim To explore the correlation between arterial elasticity indexes and serum high sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9) in patients with coronary heart disease. Methods Large arterial elasticity index ( Cl) and small arterial elasticity index (C2) were measured with CVProfilor DO-2020. Serum hs-CRP and MMP-9 were measured with ABC-double-antibody sandwich ELISA. Results There was significant difference between coronary heart disease group and control group in Cl, C2, MMP-9 and hs-CRP. Logistic regression a-nalysis showed that male, smoking, low density lipoprotein cholesterol, C2, history of hypertension, hs-CRP were independent risk factors for coronary heart disease. Significant inverse correlation was noted between Cl and hs-CRP ( r = -0.51), MMP-9 (r= -0.49), and between C2 and hs-CRP (r = -0.69), MMP-9 (r= -0.55) (allP<0.01) in patients with coronary heart disease. Multiple linear regression analysis showed that independent risk factors for Cl included age, pulse pressure, systolic blood pressure, hs-CRP, low density lipoprotein cholesterol and MMP-9, and independent risk factors for C2 were age, pulse pressure, fasting blood sugar, hs-CRP and low density lipoprotein cholesterol in patients with coronary heart disease. Conclusions The present study showed that there was significantly negative correlation between arterial elasticity indexes and serum MMP-9 and hs-CRP in patients with coronary heart disease. The in-flammation may have important impact on arterial elasticity.关键词
冠心病/动脉弹性/高敏C反应蛋白/基质金属蛋白酶9Key words
Coronary Heart Disease/ Arterial Elasticity/ High Sensitivity C-reactive Protein/ Matrix Metalloproteinase-9分类
医药卫生引用本文复制引用
万招飞,张娇,薛嘉虹,刘小军,王新宏,赵艳,吴岳,袁祖贻..冠心病患者动脉弹性与血清高敏C反应蛋白和基质金属蛋白酶9的相关性[J].中国动脉硬化杂志,2012,20(11):1003-1006,4.基金项目
国家自然科学基金资助项目(81025002 （）
81100209) （）
